Overview
Developmental Systems Biology
Information
My lab studies gene regulatory networks and cell physiological mechanisms that direct animal development. We use the fruit fly, Drosophila melanogaster, as a model organism. Our multidisciplinary work is composed of two research programs and uses methods from genetics, cell biology, biochemistry, molecular biology, and bioinformatics.
- Developmental Dynamics-The questions that drive our developmental dynamics research projects aim to determine the key components of Drosophila matrisome that direct tubulogenesis in the embryo. Model tubular organs studied include (i) the embryonic salivary gland, (ii) trachea, and (iii) the heart.
- Integrative Systems Biology-The questions that motivate our systems biology initiative explore the effects of exercise physiology on stem cell dynamics. We ask how exercise affects stem cell health by focusing on the cellular and extracellular mechanisms that calibrate stem cell homeostasis in response to systemic training adaptations.
- Teaching Interests: Cell and Developmental Biology, Evolutionary Developmental Biology of Organs and Organ Systems.
- Teaching Experience: Cell Physiology (Johns Hopkins University School of Medicine); Neurophysiology (University of Kansas School of Medicine)
- 黑洞社区 Courses: Biol 497/797 (Fall 2022)
Research Articles, Reviews, and Editorials
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function
Journal of Cell Biology (2022) Apr 4; 221(4) DOI: 10.1083/jcb.20211073
Loganathan, R., Levings, D.C., Kim, J.H., Wells, M.B., Chiu, H., Wu, H., Slattery, M., Andrew, D.J. - Secrets of secretion-how studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying
secretory organ form and function.
Current Topics in Developmental Biology (2021), Volume 143.
Loganathan, R., J.H. Wells, M.B., Andrew, D.J. - Extracellular Matrix Dynamics in Biology, BIoengineering, and Pathology
Frontiers in Cell and Developmental Biology (2020). Aug 21; 8: 759.
Loganathan, R., Little, C.D., Rongish, B.J. - Extracellular matrix dynamics in tubulogenesis
Cell Signal (2020), 72: 109619.
Loganathan, R., Rongish, B.J., Little, C.D. - CrebA increases secretory capacity through direct transcriptional regulation of the
secretory machinery, a subset of secretory cargo, and other key regulators
Traffic (2020, 21 (9), 560-577.
Johnson, D.M., Wells, M.B., Fox, R., Lee, J.S., Loganathan, R., Levings, D., Bastien, A., Slattery, M., Andrew, D.J. - Organogenesis of the Drosophila respiratory system
Organogenetic gene networks (2016), pp. 151-211.
Loganathan, R., Cheng, Y. L., Andrew, D.J. - Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through
transcriptional activation and repression
Developmental Biology (2016), 409 (1), 234-50.
Loganathan, R., Lee, J.S., Wells, M.B., Grevengoed, E., Slattery, M., Andrew, D.J. - Extracellular matrix motion and early morphogenesis
Development (2016), 143 (12), 2056-2065.
Loganathan, R., Rongish, B.J., Smith, C.M., Filla, M.B., Czirok, A., B茅naz茅raf, B., Little, C.D. - Identification of emergent motion compartments in the amniote embryo
Organogenesis (2014), 10 (4), 350-364.
Loganathan, R., Little, C.D., Joshi, P., Filla, M.B., Cheuvront, T.J., Lansford, R., Rongish, B.J. - The role of sleep in motor learning
Journal of Postdoctoral Research (2014), 2(4), 18-29.
Loganathan, R. - Spatial anisotropies and temporal fluctuations in the extracellular matrix network
texture during early embryogenesis
PLOS ONE (2012), 7 (5): e38266.
Loganathan, R., Potetz, B.R., Rongish, B.J., Little, C.D. (2012). - Exercise induced cardiac performance in autoimmune (type 1) diabetes is associated
with a decrease in myocardial diacylglycerol
Journal of Applied Physiology (2012), 113 (5), 817-826.
Loganathan, R., Novikova, L., Boulatnikov, I., Smirnova, I.V. - Time鈥揹ependent alterations in rat macrovessels with type 1 diabetes
Experimental Diabetes Research (2012), 278620.
Searls, Y., Smirnova, I.V., Vanhoose, L., Fegley, B., Loganathan, R., Stehno-Bittel, L. - Electrocardiographic changes with the onset of diabetes and the impact of aerobic
exercise training in the Zucker Diabetic Fatty (ZDF) rat
Cardiovascular Diabetology (2010), 9:56.
VanHoose, L., Sawers, Y., Loganathan, R., Vacek, J.L., Stehno-Bittel, L., Novikova, L., Al-Jarrah, M., Smirnova, I.V. - Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered
with type1 diabetes due to the direct effects of hyperglycemia
Cardiovascular Diabetology (2010), 9:8.
Searls, Y.M., Loganathan, R., Smirnova, I.V., Stehno-Bittel, L. - Exercise training improves cardiac performance in diabetes: in vivo demonstration
with quantitative cine-MRI analyses
Journal of Applied Physiology (2007), 102 (2), 665-672.
Loganathan, R., Bilgen, M., Al-Hafez, B., Zhero, S.V., Alenezy, M.D., Smirnova, I.V. - Exercise induced benefits in individuals with type 1 diabetes
Physical Therapy Reviews (2006), 11, 77-89.
Loganathan, R., Searls, Y., Smirnova, I.V., Stehno-Bittel, L. - Cardiac dysfunction in the diabetic rat: Quantitative evaluation using high resolution
magnetic resonance imaging
Cardiovascular Diabetology (2006), 5:7.
Loganathan, R., Bilgen, M., Al-Hafez, B., Alenezy, M.D., Smirnova, I.V. - Characterization of alterations in diabetic myocardial tissue using high resolution
MRI
International Journal of Cardiovascular Imaging (2006), 22 (1), 81-90.
Loganathan, R., Bilgen, M., Al-Hafez, B., Smirnova I.V. - CXCL-10 induced cell death in neurons: Role of calcium dysregulation
European Journal of Neuroscience (2006), 23 (4), 957-64.
Sui, Y., Stehno-Bittel, L., Li, S., Loganathan, R., Pinson, D., Narayan, O., Buch, S.
Books
- Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology (Volume-II)
Frontiers in Cell and Developmental Biology (In progress).
Loganathan, R., Yanagisawa, H., Little, C. D., Gentleman, E., Weiss, J., Eds. - Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology (Volume-I)
Frontiers in Cell and Developmental Biology (2020). doi: 10.3389/978-2-88966-119-0 Loganathan, R., Little, C. D., Rongish, B. J., Eds.
2022 鈥 present: Assistant Professor, 黑洞社区
2018 鈥 2022: Research Associate, Johns Hopkins University
2011 鈥 2018: Research Fellow, Johns Hopkins University
2021: Johns Hopkins Core Coins Pilot Grant for Genome Research
2016: Johns Hopkins Core Coins Pilot Grant for Proteomics Research
2006: American Heart Association Predoctoral Fellowship
Editorial Board 鈥 Frontiers in Cell and Developmental Biology (section on cell growth
and division)
Guest Associate Editor 鈥 Frontiers in Cell and Developmental Biology (section on cell
adhesion and migration)
Session Co-Chair 鈥 鈥淧atterning, Morphogenesis, and Organogenesis,鈥 63rd Annual Drosophila
Meeting, Genetics Society of America
Session Co-Chair 鈥 鈥淭he Dynamic Extracellular Matrix,鈥 2022 Annual Meeting of the
American Association for Anatomy
Invited Panelist 鈥 The Future of Research Symposium (2019) by the University of Maryland/Johns
Hopkins University/Elsevier
Institution | Degree | Year | Field of Study |
---|---|---|---|
Government Institute of Rehabilitation Medicine-Madras Medical College | BPT | 2000 | Physical Therapy |
University of Kansas | MS | 2007 | Electrical Engineering (Developmental Biology) |
University of Kansas Medical Center | PhD | 2007 | Rehabilitation Science (Cardiovascular Pathophysiology) |